The safety and effectiveness of imiquimod cream 5% were evaluated in the treatment of molluscum contagiosum (MC) in children. Twenty-three children ranging in age from 1 to 9 years with MC infection were randomized to either imiquimod cream 5% (12 patients) or vehicle (11 patients). Parents applied study drug to patient's lesions 3 times a week for 12 weeks.

Abstract

The safety and effectiveness of imiquimod cream 5% were evaluated in the treatment of molluscum contagiosum (MC) in children. Twenty-three children ranging in age from 1 to 9 years with MC infection were randomized to either imiquimod cream 5% (12 patients) or vehicle (11 patients). Parents applied study drug to patient's lesions 3 times a week for 12 weeks. Buy aldara cream - Patients presented to the clinic every 2 weeks until the end of study (week 12) for safety evaluation and lesion count. Local skin reactions, partial and complete clearances, and lesion counts were statistically analyzed. Partial clearance (> or = 30% clearance of lesions) at weeks 4 and 12 was noted in 58.3% (7/12) and 66.7% (8/12) of imiquimod patients and in 0% (0/11) and 18.2% (2/11) of vehicle patients (imiquimod vs vehicle: week 4, P = .0046; week 12, P = .0361). Complete clearance at week 12 was noted in 33.3% (4/12) of imiquimod patients and in 9.1% (1/11) of vehicle patients. The mean percentage change in lesion count at week 12 was -45.9% in the imiquimod group and +26.9% in the vehicle group. Imiquimod was well tolerated and appears to be a promising therapeutic option in the treatment of MC in children. Larger studies are needed to confirm the results of this small pilot study.

How Aldara affects the immune system

Aldara cream works to treat genital warts caused by the human papilloma virus (HPV).

Imiquimod — the active ingredient in Aldara cream — does this by working to eradicate HPV, rather than just treating the wart itself.

Imiquimod acts as an immune response modifier (IRM), helping the body stimulate its own defence mechanisms. This essentially tells the body’s immune system to attack the virus itself, releasing chemicals to attack and kill the virus, stopping HPV from multiplying in cells, as well as reducing cell abnormalities. When the HPV type 6 & 11 are killed, your genital warts should clear.

Warts treated with Aldara are less likely to recur, and you may never even have them again.

Local Inflammatory Reactions

Intense local inflammatory reactions including skin weeping or erosion can occur after few applications of Aldara Cream and may require an interruption of dosing . Aldara Cream has the potential to exacerbate inflammatory conditions of the skin, including chronic graft versus host disease.

Severe local inflammatory reactions of the female external genitalia can lead to severe vulvar swelling.

Severe vulvar swelling can lead to urinary retention. Dosing should be interrupted or discontinued for severe vulvar swelling.

Administration of Aldara Cream is not recommended until the skin is completely healed from any previous drug or surgical treatment.

Before taking this medicine

Do not use imiquimod topical for genital warts on a child younger than 12 years old. http://www.skintherapyletter.com/basal-cell-carcinoma/imiquimod-bcc-treatment/ All other uses of this medication are for adults over 18 only.

Tell your doctor if you have ever had:

a weak immune system or autoimmune disorder;

a sunburn or other skin problems; or

If you are treating the genital or rectal area, avoid sexual activity while the medicine is on your skin. Imiquimod topical can weaken rubber condoms or diaphragms, which could break during sex and result in an unplanned pregnancy.

Tell your doctor if you are pregnant or breastfeeding.

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